A friend of mine posted a note about this on his facebook page, so that's how I found it. It's very powerful.
Steve Jobs 2005 Commencement Speech at Stanford University. It's called, “Stay hungry. Stay foolish.”
The best way to get what he is saying is to start the youtube video, and listen to it while reading the transcript and following him. You'll catch more than if you just do one or the other.
Video: http://www.youtube.com/wat
Transcript: http://news-service.stanfo
Very inspirational.